The Embryonic Specification of Interneurons

Interneuron development is intimately linked to their ultimate function.

 

Interneuron Integration into the Cortical Layers

In one of the most remarkable events in neural development, newly born interneurons disperse throughout the brain to populate strikingly distinct structures including the cortex, hippocampus, striatum and amygdala.

 

 

Interneuron Function and Dysfunction

We are interested in determining the genetic and developmental origins of inhibitory interneuron diversity.

 

Building a Toolkit for Targeting Interneurons Across Mammalian Species

We are leveraging the use of transcriptomics, coupled with examination of the chromatin landscape to identify enhancers for interneuron subtypes. By using these enhancers to direct the expression of viruses (in our case Associated Adenovirus), we are able to visualize and study the function of specific interneuron subtypes