Emilia Favuzzi, PhD
Education and Training:
2017-present Postdoctoral associate, Gord Fishell lab, Broad Institute of Harvard and MIT & Harvard Medical School, USA
2011-2017 Ph.D. in Neuroscience (summa cum laude), University Miguel Hernandez of Elche, Spain and King’s College London, UK. Beatriz Rico lab.
2008-2010 M.Sc. (Hons) in Neurobiology, Sapienza University of Rome, Italy.
2004-2008 B.Sc. (Hons) in Biological Sciences, Sapienza University of Rome, Italy.
Current or Past Study:
During my postdoc, I will investigate whether interactions between microglia and GABAergic interneurons are required for neural circuit development.
In the recent years, microglia and inhibitory neurons have independently emerged as critical regulators of developmental milestones in the assembly of neural circuits and insults to both cell types have been implicated in neurodevelopmental diseases such as autism or schizophrenia. It is, therefore, conceivable to hypothesize that microglia and interneurons engage in functional interactions that sculpt the organization of neural circuits. Specifically, in collaboration with the Stevens lab, we wish to explore whether microglia prune inhibitory synapses and if so whether this is a generic or specific process. Identifying whether microglia play a role in remodeling inhibitory circuits may broaden our knowledge on the fundamental mechanisms by which different cell types acquire their final connectivity and how such connections are remodeled and organized in functional networks.