Michael Rutlin, PhD
Postdoctoral Fellow at Columbia University, NY
Education and Training:
- 2013-present: Postoctoral Fellow, Columbia University
- 2011-2013: Postdoctoral Fellow, Brandeis University
- 2011: Ph.D. in Neuroscience, Johns Hopkins University
- 1999-2003: Research Technician, Gordon Fishell Lab, Skirball Institute, NYU School of Medicine
- 1999: B.S. University of Wisconsin-Whitewater
Current or Past Study:
- Investigating the requirement of Sonic Hedgehog for progenitor cell maintenance in telencephalic stem cell niches.
- Elucidating the mechanisms by which Notch 1 promotes FGF-responsive neural stem cell identity in the telencephalon.
- Even though these topics cover a broad range, the work above suggests that specific links exist between the mechanisms that control growth and regional patterning in the developing nervous system. Two fundamental issues were addressed in these studies. First, Sonic Hedgehog, a factor that has long been proposed to act as a morphogen, also appears to play a dual role in controlling proper cellular proliferation and the maintenance of stem cell niches. Conversely, we demonstrate that Notch and FGF signaling pathways cooperate together to maintain a balance of stem cell and postmitotic populations, without overtly effecting regional patterning. The cross talk between signals that control growth and patterning is a fundamental one and one I plan to explore further in graduate school.